Gangguan pada Sistem Urinaria dan Pengobatan Herbal: Sebuah Studi Meta-Analisis

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Arikah Putri Afriani
Fairuz Najla Rachmadani
Rifky Adi Saputra
Rusdi
Sri Rahayu

Abstract

Urinary tract infection is a type of infection that occurs in one or all organs in the urinary system and is generally caused by bacterial infections, one of which is Klebsiella pneumonia. Treatment of urinary tract infections is carried out by administering antibiotics, however, this method actually increases the incidence of antibiotic resistance. Therefore, alternative treatments are needed to replace the antibiotics used for urinary tract infections. This is a meta-analysis study that aims to obtain information about alternative treatments for urinary tract infections using herbal medicines and their mechanisms. This research begins with a search for relevant references, then selecting the articles that are truly relevant with the topic, and extracting the data. The data used was secondary data extracted from the references, then statistically tested with Ancova t-test and effect size calculation. The extraction results showed that the usage of herbal plant extracts was able to provide an inhibitory zone on the growth of Klebsiella pneumonia, which indicates that herbal plant extracts are able to provide antipathogenic effects for Klebsiella pneumonia. The Ancova t-test results showed a sig. value is 0.000 which indicates that there is a clear and significant effect of the herbal plants extract as an anti-uropathogen of Klebsiella pneumonia. The calculation of effect size also showed a value is 0.882 which means that the herbal plants used as an anti-uropathogen of Klebsiella pneumonia has a very large effect.

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How to Cite
Afriani, A. P., Rachmadani, F. N., Saputra, R. A., Rusdi, & Rahayu, S. . (2024). Gangguan pada Sistem Urinaria dan Pengobatan Herbal: Sebuah Studi Meta-Analisis. Jurnal Sains Dan Kesehatan, 3(2), 79–87. https://doi.org/10.57151/jsika.v3i2.923
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References

Ahmad, Q., Sabrina, T., Diba, M. F., Amalia, E., & Putra, R. A. (2022). Gambaran Infeksi Klebsiella pneumoniae Penghasil Extended-spectrum β-lactamase (ESBL) Pada Pasien COVID-19 di RSUP Dr. Mohammad Hoesin Periode Januari 2021- JUni 2021. JAMBI MEDICAL JOURNAL, 10(2), 186–198. https://online-journal.unja.ac.id/kedokteran/article/view/19220

Alamri, F., Fatimawali, F., & Jayanto, I. (2020). UJI DAYA HAMBAT EKSTRAK HEKSANA RIMPANG LENGKUAS MERAH (Alpinia purpurata K. Schum) TERHADAP BAKTERI Klebsiella pneumoniae ISOLAT URIN PADA INFEKSI SALURAN KEMIH. Pharmacon, 9(1), 47. https://doi.org/10.35799/pha.9.2020.27409

Anggraini, N. D., Kartika, K. M., & Sari Tambunan, E. P. (2022). Uji Efektivitas Antibakteri Ekstrak Etanol Bunga Kecombrang (Etlingera elatior) Terhadap Pertumbuhan Klebsiella pneumoniae. KLOROFIL: Jurnal Ilmu Biologi Dan Terapan, 6(1), 38. https://doi.org/10.30821/kfl:jibt.v6i1.11648

Biondo, C. (2023). Bacterial Antibiotic Resistance: The Most Critical Pathogens. Pathogens, 12(1), 0–1. https://doi.org/10.3390/pathogens12010116

Chayati, I., Kelen, A., & Astuti, T. D. (2024). UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK PARE BELUT ( TRICHOSANTHES CUCUMERINA L ) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA DAN KLEBSIELLA PNEUMONIAE. Jurnal Kesehatan Tambusai, 5(3), 6601–6605.

Chrismayanti, N. K. S. D., Suastini, K. D., Cawis, N. L. S. A., & Dewei, N. W. S. (2021). Pengaruh Ekstrak Jahe Merah (Zingiber Officinale.) Terhadap Pertumbuhan Bakteri Shigella Dysentriae. Hang Tuah Medical Journal, 18(2), 136. https://doi.org/10.30649/htmj.v18i2.478

Das, S. (2020). Natural therapeutics for urinary tract infections—a review. Future Journal of Pharmaceutical Sciences, 6(1), 1–13. https://doi.org/10.1186/s43094-020-00086-2

Ding, Y., Wang, H., Pu, S., Huang, S., & Niu, S. (2021). Resistance trends of klebsiella pneumoniae causing urinary tract infections in Chongqing, 2011–2019. Infection and Drug Resistance, 14, 475–481. https://doi.org/10.2147/IDR.S295870

Fazly Bazzaz, B. S., Darvishi Fork, S., Ahmadi, R., & Khameneh, B. (2021). Deep insights into urinary tract infections and effective natural remedies. African Journal of Urology, 27(1). https://doi.org/10.1186/s12301-020-00111-z

Huang, L., Huang, C., Yan, Y., Sun, L., & Li, H. (2022). Urinary Tract Infection Etiological Profiles and Antibiotic Resistance Patterns Varied Among Different Age Categories: A Retrospective Study From a Tertiary General Hospital During a 12-Year Period. Frontiers in Microbiology, 12(January), 1–10. https://doi.org/10.3389/fmicb.2021.813145

Iien, H., Zulkifli, L., & Sedijani, & P. (2020). Jurnal Biologi Tropis Aktivitas Antibakteri Ekstrak Metanol Daun Turi ( Sesbania grandiflora L .) Terhadap Pertumbuhan Klebsiella pneumoniae. Aktivitas Antibakteri Ekstrak Metanol Daun Turi (Sesbania Grandiflora L.) Terhadap Pertumbuhan Klebsiella Pneumoniae, 20(2), 219–226. https://doi.org/http://dx.doi.org/10.29303/jbt.v20i2.1790

Juariah, S., Bakar, F. I. A., Bakar, M. F. A., Endrini, S., Kartini, S., Mohamad, A., & Hanafi, A. F. M. (2023). Antibacterial Activity of Red Ginger (Zingiber officinale var. rubrum) and Black Turmeric (Curcuma caesia) Extracts as Growth Inhibitors of Klebsiella pneumonia. Tropical Journal of Natural Product Research, 7(8), 3658–3665. https://doi.org/10.26538/tjnpr/v7i8.14

Klein, R. D., & Hultgren, S. J. (2020). Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies. Nature Reviews Microbiology, 18(4), 211–226. https://doi.org/10.1038/s41579-020-0324-0

Kurama, G. M., Maarisit, W., Karundeng, E. Z., & Potalangi, N. O. (2020). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Benalu Langsat (Dendropthoe sp) Terhadap Bakteri Klebsiella Pneumoniae. Biofarmasetikal Tropis, 3(2), 27–33. https://doi.org/10.55724/j.biofar.trop.v3i2.281

Li, X., Fan, H., Zi, H., Hu, H., Li, B., Huang, J., Luo, P., & Zeng, X. (2022). Global and Regional Burden of Bacterial Antimicrobial Resistance in Urinary Tract Infections in 2019. Journal of Clinical Medicine, 11, 1–14. https://doi.org/https:// doi.org/10.3390/jcm11102817

Liu, X., Sai, F., Li, L., Zhu, C., & Huang, H. (2020). Clinical characteristics and risk factors of catheter-associated urinary tract infections caused by Klebsiella Pneumoniae. Annals of Palliative Medicine, 9(5), 2668–2677. https://doi.org/10.21037/apm-20-1052

Loubet, P., Ranfaing, J., Dinh, A., Dunyach-Remy, C., Bernard, L., Bruyère, F., Lavigne, J. P., & Sotto, A. (2020). Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections. Frontiers in Microbiology, 11, 1–18. https://doi.org/10.3389/fmicb.2020.01509

Mancuso, G., Midiri, A., Gerace, E., Marra, M., Zummo, S., & Biondo, C. (2023). Urinary Tract Infections: The Current Scenario and Future Prospects. Pathogens, 12(4). https://doi.org/10.3390/pathogens12040623

McCann, E., Sung, A. H., Ye, G., Vankeepuram, L., & Tabak, Y. P. (2020). Contributing factors to the clinical and economic burden of patients with laboratory-confirmed carbapenem-nonsusceptible gram-negative respiratory infections. Infection and Drug Resistance, 13, 761–771. https://doi.org/10.2147/IDR.S236026

Murray, C. J., Ikuta, K. S., Sharara, F., Swetschinski, L., Robles Aguilar, G., Gray, A., Han, C., Bisignano, C., Rao, P., Wool, E., Johnson, S. C., Browne, A. J., Chipeta, M. G., Fell, F., Hackett, S., Haines-Woodhouse, G., Kashef Hamadani, B. H., Kumaran, E. A. P., McManigal, B., … Naghavi, M. (2022). Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet, 399(10325), 629–655. https://doi.org/10.1016/S0140-6736(21)02724-0

Rahmawati, A. N., & Solicah, P. A. (2020). UJI DAYA HAMBAT EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa Boerl.,) TERHADAP Klebsiella pneumonia. Jurnal Ilmiah Manuntung, 6(2), 209–214. https://doi.org/10.51352/jim.v6i2.349

Sathyavathy, K., & Madhusudhan, B. K. (2020). Review on Clinical Diseases Caused by Klebsiella. Journal of Pharmaceutical Research International, 32(21), 12–19. https://doi.org/10.9734/jpri/2020/v32i2130745

Söderström, B., Pittorino, M. J., Daley, D. O., & Duggin, I. G. (2022). Assembly dynamics of FtsZ and DamX during infection-related filamentation and division in uropathogenic E. coli. Nature Communications, 13(1), 1–13. https://doi.org/10.1038/s41467-022-31378-1

Utami, F. N., & Indarini, E. (2021). Meta Analisis Pengaruh Pendekatan Matematika Realistik Terhadap Kemampuan Berpikir Kritis Pada Matematika Siswa di Sekolah Dasar. Jurnal Basicedu, 5(2), 887–894. https://doi.org/10.31004/basicedu.v5i2.852

Vega, S., Acosta, F., Landires, I., Morán, M., Gonzalez, J., Pimentel-Peralta, G., Núñez-Samudio, V., & Goodridge, A. (2021). Phenotypic and genotypic characteristics of carbapenemase- and extended spectrum β-lactamase-producing Klebsiella pneumoniae ozaenae clinical isolates within a hospital in Panama City. Therapeutic Advances in Infectious Disease, 8, 1–8. https://doi.org/10.1177/20499361211054918

Zagaglia, C., Ammendolia, M. G., Maurizi, L., Nicoletti, M., & Longhi, C. (2022). Urinary Tract Infections Caused by Uropathogenic Escherichia coli Strains—New Strategies for an Old Pathogen. Microorganisms, 10(7), 1–12. https://doi.org/10.3390/microorganisms10071425